Martha C. Tissot van Patot, Ph.D. Biography

Martha C. Tissot van Patot, Ph.D. Biography
Selected Peer-Reviewed Scientific Publications
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Tissot van Patot, MC. Getting Lost in History: Mabel Purefoy FitzGerald and the Origins of Hydrochloric Acid in the Gastric Mucosa. Function 2(6): 1-4, 2021.
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Tana W, Noryung T, Burton GJ, Tissot van Patot MC, Ri-Li G. Protective Effects from the Ischemic/Hypoxic Stress Induced by Labor in the High-Altitude Tibetan Placenta. Reprod Sci. 28 (3): 659-664, 2021.
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Liu H, Tenzing N, Tissot van Patot MC, Ge R-l, Wuren T. Enhanced placental mitochondrial respiration in Tibetan women at high altitude. Frontiers in Physiology. 12, 2021.
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Veerbeek JH, Tissot van Patot MC, Burton GJ, Yung H-W. Endoplasmic reticulum stress is induced in the human placenta during labour. Placenta. 36 (1): 88-92, 2015.
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Cindrova-Davies T, Tissot van Patot MC, Gardner L, Jauniaux E, Burton GJ, Charnock-Jones DS. Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development. Mol Hum Reprod. 21(3): 296-308, 2015.
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Colleoni F, Padmanabhan N, Yung H-w, Watson ED, Cetin I, Tissot van Patot MC, Burton GJ, and Murray AJ. Suppression of Mitochondrial Electron Transport Chain Function in the Hypoxic Human Placenta: A Role for miRNA-210 and Protein Synthesis Inhibition. PLoS ONE 8: e55194, 2013.
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Yung HW, Cox M, Tissot van Patot MC. Burton G. Evidence of endoplasmic reticulum stress and adaptive protein synthesis inhibition in the high-altitude human placenta. FASEB Journal 26(5): 1970-81, 2012.
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Gassmann M, Ogunshola OO, Tissotv van Patot MC. Meeting Report: The impact of hypoxia on mice and men. High Alt Med Biol 13(1) 63-64, 2012.
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Yakushev S, Band M, Tissot van Patot MC, Gassmann M, Avivi A, Bogdanova A. Cross talk between S-nitrosylation and S-glutathionylation in control of the Na,K-ATPase regulation in hypoxic heart. Am J Physiol Heart Circ Physiol. 303 (11): H1332-1343, 2012.
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Tissot van Patot MC. Gassmann, M. Hypoxia: adapting to high altitude by mutating EPAS-1, the gene encoding HIF-2a. High Alt Med Biol 12(2): 157-167, 2011.
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Tissot van Patot MC, Murray AJ, Beckey V, Cindrova-Davies T, Johns J, Zwerdlinger L, Jauniaux ERM, Burton GJ, and Serkova NJ. Human placental metabolic adaptation to chronic hypoxia, high altitude: Hypoxic pre-conditioning. Am J Physiol Regul Integr Comp Physiol 298: R166-R172, 2010.
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Gassmann M, Tissot van Patot MC, Soliz J. The neuronal control of hypoxic ventilation: erythropoietin and gender dimorphism. Ann N Y Acad Sci 1177: 151-161, 2009.
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Irwin D, Beuhler P, Alayash A, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, Tissot van Patot MC, Hamilton KL, and Gotshall RW. Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acute hypoxic rats. American Journal of Respiratory Cell and Molecular Biology 42(2) 200-209, 2010.
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Irwin DC, Becky G, Foreman B, Sullivan T, Crossno JT, Jr., McCord JM, Bailey DM, Flores SC, Majka S, Klemm DJ, Tissot van Patot MC. A potential role for reactive oxygen species and the HIF-1α-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radic Biol Med 47(1): 55-61, 2009.
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Tissot van Patot MC, Valdez M, Becky V, Cindrova-Davies T, Johns J, Jauniaux E, Burton GJ. Pregnancies at altitude in non-native women with and without preeclampsia yield smaller, yet morphologically similar to placentas in sea level pregnancies. Placenta 30: 523-528, 2009.
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Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DF, Roach RC, Christians U, Henthorn TK, Honigman B. Enhanced leukocyte HIF-1 alpha and HIF-1 DNA-binding in humans following rapid ascent to 4300m. Free Radic Biol Med 46(11): 1551-1557, 2009.
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Tissot van Patot MC, Keyes LE, Leadbetter G, Hackett PH. Ginkgo biloba for prevention of acute mountain sickness: Does it work? High Altitude Medicine & Biology 10: 33-43, 2009.
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Gotshall RW, Hamilton KL, Foreman B, Tissot van Patot MC, Irwin DC. Gluteraldehyde-Polymerized Bovine Hemoglobin and Phosphodiesterase-5 Inhibition. Crit Care Med 37(6): 1988-1993, 2009.
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Leadbetter, III G, Keyes LE, Maakestad KM, Olson S, Tissot van Patot MC, and Hackett PH. Ginkgo biloba does . . . and does not prevent acute mountain sickness. Wilderness and Environmental Medicine Journal, 20(1): 66-77, 2009.
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Elkiweri IA, Tissot van Patot MC, Zhang Y, Christians U, Henthorn T. The Effect of Loperamide and Fentanyl on the Distribution Kinetics of Verapamil in the Lung and Brain in Sprague Dawley Rats. World Academy of Science, Engineering and Technology, International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering. 3: 372-377, 2009.
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Elkiweri IA, Zhang YL, Christians U, Ng K-Y, Tissot van Patot, MC, Henthorn TK. Competitive Substrates for P-Glycoprotein and OrganicAnion Protein Transporters Differentially Reduce Blood Organ Transport of Fentanyl and Loperamide: Pharmacokinetics and Pharmacodynamics in Sprague-Dawley Rats. Anesth Analg 108(1): 149-159, 2009.
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Tissot van Patot MC, Leadbetter III, G, Keyes LE, Maakestad KM, Olson S, and Hackett PH. Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness. High Altitude Medicine and Biology, v. 9(4): 289-292, 2008.
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Irwin DC, Foreman B, Morris K, White M, Sullivan T, Jacobs R, Monnet E, Hackett T, Tissot van Patot MC, Hamilton KL, and Gotshall RW. Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat. American Journal of Physiology Heart and Circulatory Physiogy, 295: H1090-H1099, 2008.
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Soliz, J, Soulage, C, Borter, E, Tissot van Patot, MC, Gassmann, M. Ventilatory responses to acute and chronic hypoxia are altered in female but not male PASKIN-deficient mice. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 295: R649-R658, 2008.
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Serkova N, Reisdorph N, Tissot van Patot MC. Metabolic Markers of Hypoxia: Systems Biology Application in Biomedicine. Toxicology Mechanisms and Methods, vol. 18, p.1-15, 2008.
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Cartwright JE, Keogh RJ, Tissot van Patot MC. Hypoxia and placental remodeling. Adv Exp Med Biol 618, 113-126, 2007.
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Engebretsen BJ, Irwin D, Valdez ME, O’Donovan MK, Tucker A, Tissot van Patot MC. Acute hypobaric hypoxia (5,486 m) induces greater pulmonary HIF-1 activation in Hilltop compared to Madison rats. High Altitude Medicine and Biology, vol. 4(8) p. 312-321, 2007.
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Tissot van Patot, MC, Hill, AE, Dingmann, C, Gaul, L, Fralick, K, Christians, U, Honigman, B, Salman, MD. Risk of sub therapeutic coagulation in warfarin patients ascending to altitude (>8,000 feet). High Altitude Medicine and Biology, vol. 7(1), p. 39-46 2006.
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Irwin, DC. Tissot van Patot, MC, Tucker, A. Bowen, R. Neutral Endopeptidase Null Mice are Less Susceptible to High Altitude Induced Pulmonary Vascular Leak. High Altitude Medicine and Biology, High Altitude Medicine and Biology, vol. 6(4), p. 311-319, 2005.
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Tissot van Patot, MC, Leadbetter, G, Keyes, LE, Bendrick-Peart, J, Beckey, VE, Christians, U, and Hackett, P. Greater free plasma VEGF and lower soluble VEGF receptor-1 in Acute Mountain Sickness. Journal of Applied Physiology, v. 98, p. 1626-1629, 2005.
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Irwin, DC. Tissot van Patot, MC, Tucker, A. Bowen, R. Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers. American Journal of Physiology: Lung, Cell and Molecular Physiology, v. 287: L525-532, 2004.
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Serkova, N., Bendrick-Peart, J. Alexander, B., Tissot van Patot, MC., Metabolite concentrations in human term placentae and their changes due to delayed collection after delivery. Placenta, v. 24: p. 227-235, 2003.
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Tissot van Patot, MC., Bendrick-Peart, J., Beckey, V.E., Serkova, N., Zwerdlinger, L. Greater vascularity, lowered HIF-1/DNA binding and elevated GSH as markers of adaptation to in vivo chronic hypoxia. American Journal of Physiology: Lung, Cell and Molecular Physiology, 287: L525-L532, 2004.
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Tissot van Patot, MC., Tucker, A., Voelkel, NF. Endotoxin-induced adhesion of red blood cells to pulmonary artery endothelial cells. American Journal of Physiology: Lung, Cellular and Molecular Physiolgy.
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Tissot van Patot, MC., Seim III, HB., Tucker, A. Catheterization of the subarachnoid space in rabbits using a Vascular Access Portä. Journal of Investigative Surgery, vol. 8: 371-379, 1995.